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Well, these are just some of the conditions liked to a faulty enzyme called MTHFR

DiNicolantonio, Dietary Glycine Is Rate-Limiting for Glutathione Synthesis and May Have Broad Potential for Health Protection, Ochsner J

(4) aligning the highly conserved modules to the gene expression profiles perturbed by small molecular compounds in CMAP database 41,42 , and identifying the gene expression profiles enriched in genes from the conserved modules