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The compound has been in pre-clinical investigation for decades

A unifying feature is their ability to mitigate oxidative stressfor example, many flavonoids, alkaloids, and saponins activate the Nrf2/ARE pathway, upregulating endogenous antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) to neutralize excess reactive oxygen species (Wang Q

Liu C, Liu X, Xiang X, Pang X, Chen S, Zhang Y, Ren E, Zhang L, Liu X, Lv P, Wang X, Luo W, Xia N, Chen X, Liu G

Nonetheless, it is statistically challenging to determine whether the outcome was caused by the pharmacological agent itself, the illness being treated, or a complex interaction between the two

The gene has been identified in 1999 and annotated on chromosome 10 (Halestrap and Price, 1999)