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These bigwigs, along with the previously obtained induced and reduced peaks in bed format, were input into deeptools computeMatrix, and the output was plotted using deeptools plotHeatmap reference-point

10.1016/j.niox.2017.10.010 17 DuanS

Shifting to every-other-day administration during weeks 46 reduces cumulative receptor occupancy and slows further desensitization while still maintaining therapeutic plasma IGF-1 LR3 levels, extending the effective anabolic window by 12 weeks compared to continuous daily dosing that plateaus completely by week 5

Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia

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