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Brain Res 877(2):407410 Levine A et al (2017) Evidence for the risks and consequences of adolescent cannabis exposure

An acceptable safety and tolerability profile was also observed in phase 1/2 studies

These studies demonstrated a decreased dendritic spine number in the cortex [373] and hippocampus [374]

They will reach liver and be degraded into valine, leucine, isoleucine, and other amino acids, and these excess compounds were likely to activate Hippo signaling and synergistically exacerbate liver injury