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These findings have generated significant research interest in the compound as a tool for investigating HGF/c-Met-associated signaling networks, synaptic regulatory processes, and molecular pathways governing neuronal connectivity

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Neuroprotection Protects Brain Cells: By increasing brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), Semax supports the survival and growth of neurons

Nevertheless, despite demonstrating potent in vivo effects, neither study performed side-by-side dose-response benchmarking against clinical ACE inhibitors (e.g., lisinopril or captopril) under identical assay conditions