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Description

Extracellular NAD + can enter cells via pore-forming channel connexin 43 (Cx43), a bi-directional NAD + transporter allowing exogenous NAD + transportation into the cell, and transportation out for utilization of NAD + by CD38 64

Furthermore, the detection and quantification of SPMs have posed challenges or controversies due to their relatively low concentrations in circulation, urine, and tissues