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No adverse systemic effects have been documented during topical use

In Mouse Hepatic Neoplasia (Butler W

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Ethics declarations Ethics approval and consent to participate This research received approval from the National Center for Health Statistics Research Ethics Review Board, and participants signed informed consent forms (Protocol #201117)

Signalling within the cancer cells Numerous molecular pathways affecting malignant cholangiocytes have been identified, leading to the sub-classification of CCA into inflammatory or proliferative classes characterized by the induction of pro-inflammatory signals and the activation of oncogenic cascades 1,80,123