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Its systemic reach is one of its defining characteristics and what separates it from more localized peptides

This partial sequence from human gastric protective protein BPC, which is naturally found in the human digestive tract and has been derived from human gastric juices was discovered in the 1990s by a group of scientists studying its impact mostly on gastrointestinal functions and wound healing

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Additionally, SUMOylation of transcription factors impairs their nuclear localization, further disrupting hormonal signaling cascades (62, 63)

To overcome this issue, some engineering processes envisage the loading of said binding proteins in order to increase the binding capacity of RBCs