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The cells in Method 2 reached confluence and became growth arrested at the end of hepatic specification

Trade-offs also arise between material stability and stimuli responsiveness, between prolonged circulation and adequate tissue exposure, and between local intensification of effects and systemic safety [60, 62]

Mechanism of Action Ketorolac competitively inhibits both cyclooxygenase (COX) isoenzymes, COX-1 and COX-2, by blocking arachidonate binding resulting in analgesic, antipyretic, and anti-inflammatory pharmacologic effects

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Twenty-two patients were enrolled in the study and were assigned to one of five cohorts receiving a single IV infusion of pegadricase (0.1, 0.2, 0.4, 0.8, or 1.2 mg/kg) (Supplementary Figure 1)