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The pituitary gland, a central gland of the endocrine system within the animal body and human being, participates in regulating multiple physiological processes [20,21,22]

Similarly, oridonin effectively suppresses the EGFR/ERK/MMP-12 signalling pathway in gefitinib-resistant NSCLC cells, thereby inhibiting cell proliferation and metastasis [257]

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High-risk groups include individuals with functional or anatomic asplenia, HIV infection, leukemia, lymphoma, Hodgkins disease, multiple myeloma, generalized malignancy, chronic kidney failure, nephrotic syndrome, or other immunosuppressive conditions

( e ) Schematic of AKP organoid isolation and culture (3D and 2D cell line) with representative images of 3D or 2D cultures treated 5FU at 72 h