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Although the use of traditional medications, DMARDs, and innovative biologic agents has collectively improved treatment outcomes, numerous patients exhibit insufficient responses to existing therapies or adverse side effects, highlighting the necessity for novel treatment strategies (176)

The potential of optimising host inflammatory responses by modifying Se dietary intake has been explored in several inflammatory-based disease models such as cancer ( Reference Banning, Florian and Deubel 5 ) , CVD ( Reference Flores-Mateo, Navas-Acien and Pastor-Barriuso 6 ) , mastitis ( Reference Aitken, Karcher and Rezamand 7 ) and osteoporosis ( Reference Cheng, Stabler and Bolognesi 8 )

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Analysis of raw LC/MS data was performed using software package Compound Discoverer 2.0 (Thermo Fisher Scientific) with an in-house-generated analysis workflow and oxidized-phospholipid database

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