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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Desai B.S., Monahan A.J., Carvey P.M., Hendey B

Notable examples of successful retargeting include sildenafil (initially developed to treat angina pectoris before being repurposed as an erectile dysfunction drug) and zidovudine (originally a chemical drug before becoming the first FDA-approved anti-HIV medication)

She founded and led the COVID Taskforce, ensuring a coordinated response and implementation of health and safety policies

It could also induce overexpression of bactericidal/permeability-increasing protein (BPI) and antimicrobial peptide LL37 genes, increasing the ability of macrophages to eliminate bacterial infection (Jurez et al., 2018)

Further research should investigate how they influence key immune factors such as NK cells, neutrophils, goblet cell-stimulated mucin production, and histone deacetylase regulation in lupus models