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To examine the incorporation of GSH-derived cysteine into downstream pathways, we used an inverse stable-isotope labelling approach 34,35

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The gene CYP19A1 , identified in an OCT perturb-seq screen, was associated with increased tumor PD-L1 levels, potentially through concomitant decrease of TGF- in the TME and upregulation of activating receptor NKG2D on NK cells during CYP19A1 inhibiton [40, 122, 124]

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