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10.1016/j.diabet.2008.08.001 182 TokiS.NewcombD

Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation [4]

Further, we predicted the conformational structure of Fusion 9, which clearly illustrated that the cleavage sequence VDALA (green) is close to the catalytic residue (red) of nCPD (Fig.6f), indicating the high possibility of auto-processing approach of the fusion proteins with the engineered nCPD