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The binding between allergenic proteins and plant polyphenols changes the conformation of the protein, reducing its allergenic potential ( cis configuration has the strongest inhibitory activity ( TABLE 1 Origins and anti-allergic mechanisms of plant polyphenols

Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways

Effective therapeutic paradigms appear to converge on modulation of the mitochondrial function, purinergic signaling, and neuroinflammation, often supplemented by nutritional regulators such as vitamin D and retinoids