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The inefficient recycling of Se in BAT for the synthesis of selenoproteins, particularly GPX1 and GPX4 which are involved in adaptive thermogenesis, may potentially lead to increased oxidative stress within this tissue, yet is insufficient to curb heat production

It also exibits questionable behaviour in the presence of UV light and was the center of a debate between the non-profit group, EWG (whose intentions are no doubt good, but its credibility is often questioned by scientists) and a group of scientists and dermatologists lead by Steven Q

When toxic burden is high, toxins recirculate, detox pathways get overwhelmed, and inflammation keeps the system from moving forward

This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures