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Clin Infect Dis 1997

As a recently reviewed subject (Vukojevic et al., 2022), BPC 157 has been shown to reduce brain lesions, trauma-induced brain injury (Tudor et al., 2010), compression-induced spinal cord injury (Perovic et al., 2019), and stroke (Vukojevic et al., 2020)

Their deficiency manifests as cognitive impairment, peripheral neuropathy, and disruptions in energy metabolism [95,96]

This occurs through the direct binding of Cu ions to lipoylated components of the tricarboxylic acid cycle during mitochondrial respiration, leading to the aggregation of lipoylated proteins and the subsequent downregulation of Fe-S cluster proteins, which causes toxic stress to the proteins and ultimately leads to cell death

Construction of pET21bcyclonalMBP(chimeric) involved double digestion of pET21bcyclonalMBP(mFab/hFc) with SalI/HindIII to remove the mouse C L followed by ligation of DNA encoding human C L between the same sites