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Pfeiffer, F

Notably, a significant portion of albumin in the blood lacks the C-terminal L585 residue, ranging from 3 to 15% in healthy individuals and up to 93% in patients with pancreatitis or other pancreatic disorders 60,61,62

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Although these caspases cannot directly cleave the precursors of IL-1/IL-18, they can still trigger pyroptosis by cleaving GSDMD-NT, a process specifically activated by bacterial lipopolysaccharides [67, 68]

A patient with impaired absorption can maintain a borderline-normal serum level for a long time while their cellular B12 is progressively inadequate