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In their unmethylated forms these flavonols had previously been shown to bind weakly to At GSTF2 ( N -naphthylphthalamic acid ( At GSTF12) in arabidopsis ( At GSTF12, At GSTF2 is not essential to anthocyanin pigment biosynthesis in arabidopsis ( At GSTF2 has been linked to flavonoid metabolism in planta , showing reduced levels of expression in tt4 flavonoid-deficient mutants and a relocation to the cytosol rather than the plasma membrane ( At GSTF2 remote from the active site at the dimer interface of the protein (2), further pointing to a very specific interaction of this protein with flavonoids

In a tumor environment, reactive oxygen species, which are generated by accelerated metabolism, hypoxia or DNA damage, must be managed to maintain a high proliferative advantage for cancer cells

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