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Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2

1 Introduction The Qinghai-Tibet Plateau, with an average elevation exceeding 4,000 meters, is characterized by an atmospheric oxygen partial pressure of only 6070% of that at sea level, rendering it one of the most representative extreme hypoxic environments globally (1, 2)

Harrison SA, Wong V, Okanoue T, Bzowej N, Vuppalanchi R, Younes Z, Younossi Z (2020a) Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: results from the STELLAR Phase 3 Trials