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Special monitoring may be needed for diabetes medications (though AOD-9604 doesnt affect glucose metabolism), cardiovascular drugs, thyroid medications, or other growth hormone-related therapies

Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling