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Upon activation, NLRP3 engages the scaffold protein NIMA related kinase 7 (NEK7) and recruits the adaptor apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing (PYCARD, also known as ASC)) to assemble the inflammasome complex

Many factors deplete NAD+ levels in the body, including extensive free radical-induced DNA damage, chronic inflammation and immune activation, aging-related increase in consumption, and decrease in synthesis

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