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In order to prevent mistranslation of Asn or Gln codons, the product of these ND-aaRSs must not be liberated before reaching the amidotransferase

These findings indicate that some ALS-linked mutations in FUS/TLS lead to defects in its nuclear function, independent of cytosolic redistribution, and strongly suggest that the interaction of FUS/TLS with U1-snRNP is directly involved in FUS/TLS splicing activity

This reaction is widely used in the synthesis of alcohols and is particularly valuable in creating carbon-carbon bonds, a fundamental process in building complex organic molecules

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