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Additional studies have shown that spinal fusion may result in degeneration of adjacent discs and lead to further discogenic pain, herniation, stenosis or spondylosis, suggesting that improvements in surgical interventions for back pain are necessary (Ghiselli et al., 2004)

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It is preferred that the first coating comprises the copolymer (A) in combination with the copolymer (B) and/or the copolymer (C)

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