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10.1021/jacsau.2c00712 24 GargD.PatelN.RawatA.RosadoA

Thats despite the lack of rigorous scientific study and the three phases of human clinical trials that precede FDA approval of new drugs

Genome medicine , 4 (8), 67

Without knowing the target, the mechanism of action remains incompletely understood, and it is not possible to optimize the peptide-receptor interaction or predict off-target effects