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Similarly, 4-aminobiphenyl, metabolized by hepatic CYP1A2, produces reactive intermediates that form DNA adducts in hepatocytes, increasing the mutational burden [27]

CrossRef Social Determinants of Health in Metabolic DysfunctionAssociated Steatotic Liver Disease and AllCause/CauseSpecific Mortality Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, Rohit Loomba, Aijaz Ahmed Alimentary Pharmacology & Therapeutics .2026

The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366

This review systematically examines the mechanisms of metformin in ameliorating PCOS-associated infertility, with particular emphasis on its pleiotropic effects across critical life stagesfrom pubertal development through pregnancy to long-term health outcomes, thereby providing valuable insights into the clinical application of metformin in the treatment of PCOS