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Raghunathan, R., Sethi, M

Severe forms of congenital or acquired airway flaccidity are troublesome pathologies that are difficult to treat with a mortality as high as 80%.[103] Supportive care with a tracheostomy or positive airway pressure may be insufficient and there may not be good surgical options, including anterior or posterior pexying of the airway.[104][105][106] Internal airway stenting carries a significant risk of device migration and airway obstruction or formation of granulation tissue.[107][108] Resorbable internal stents require careful surveillance due to short resorption time and possible device migration.[109][110][111] External splints using polytetrafluorethylene (PTFE) prostheses have significant risks of death, restenosis, and airway perforation.[99][100] 3D-printed tracheal splints using resorbable polycaprolactone (PCL) have had good success in patients with severe tracheobronchomalacia at high risk of death or permanent disability

It is at present very clear that a fundamental source of both natural and immune IgM comes from specialized B-1 cell subsets, but still much needs to be known regarding the origins, development, and maintenance of B-1 cell responses (225, 226, 229, 235)

in case of malabsorption (insufficient absorption of vitamin B12 in the intestine)