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Thus, GSH plays a critical role in the restoration of cell signaling and transcriptional program during cystine starvation in HepG2 cells

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The mice were received a continuous supply of food and water

or an N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof, with the proviso that: when R 3 is ethyl, R 1 and R 2 cannot be both H, O, or when R 3 is ethyl and at least one of R 1 or R 2 is H, R 1 or R 2 cannot be As used herein, the terms modulate, modulating, modulator and grammatical variations thereof mean to change, such as decreasing or reducing the occurrence of ferroptosis

10.1038/s41582-023-00801-6 77 KongX.HuW.CuiY.GaoJ.YaoX.RenJ.et al (2022)