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Description

Category 2 Key clinical evidence Sermorelin FDA-era pediatric trials + PK data Tesamorelin Phase 3 visceral fat data CJC-1295 (DAC) Phase 1 PK and GH/IGF-1 duration data Typical research dose Sermorelin 200-300 mcg nightly Tesamorelin 2 mg daily CJC-1295 (DAC) 1-2 mg weekly Main use case Sermorelin GH optimization, sleep, recovery Tesamorelin Visceral fat / metabolic context CJC-1295 (DAC) Sustained GH/IGF-1 elevation All three target the same receptor but are not interchangeable

Evidence: Investigational (Grade D) very limited human data, mainly preclinical References: peer-reviewed IGF-1 and growth-factor physiology literature

Gut 68(8):15041515 Mayneris-Perxachs J, Moreno-Navarrete JM, Fernandez-Real JM (2022) The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism

10.1002/phar.2707 55 NowakL.BregestovskiP.AscherP.HerbetA.ProchiantzA

Though higher BDNF serum levels have been reported in carriers of the Val66Met (rs6265) polymorphism, no significant association was found with ECT response [37], corroborating earlier negative findings [38]