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Nat Protoc 4:15821590 Wilhelm L, Wendling C, Vdie B, Kobayashi T, Chenard M, Tomasetto C, Drin G, Alpy F (2017) STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites

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IGF-1 receptors undergo ligand-induced internalization and degradation when chronically stimulated, reducing cell surface receptor density by 3050% within 34 weeks in myocyte culture models

These results were used to support threshold concentrations for reporting of 5 mg/L for blood and 10 mg/L for urine