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Data availability The shotgun metagenomics dataset generated during this study (i.e., NovaSeq X Plus Series paired-end 150 fastq reads) can be found in the European Nucleotide Archive repository at: with accession number PRJEB85873.The remaining datasets used and/or analyzed during the current study are included in the manuscript or supporting files

Genetic mutations that decrease WFS1 are linked to depression, psychiatric disorders, and suicide risk.[ref][ref][ref] This is just the tip of the iceberg in terms of genes that can impact mitochondrial function

In post- and menopausal women, HRT helps manage depressive symptoms

Hydrogen sulfide and l-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT)/protein kinase czeta/lambda (PKCzeta/lambda) in 3T3l1 adipocytes

Inhibition of mTOR by rapamycin obviously impairs insulin-activated protein synthesis