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In particular, the 55 most highly expressed genes in the invasive MC58 strain included genes encoding proteins involved in amino acid transport and metabolism ( argH , aroA , aroB , ilvC , and gdhA ), genes for ATP synthase subunits ( atpA , atpD , atpG ), genes involved in sialic acid capsule biosynthesis ( siaB , siaC ), and an operon encoding Na + -translocating NADH-quinone reductase subunits ( nqrB , nqrC , nqrD )

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462 As an immunomodulatory and anti-inflammatory agent, thalidomide has been shown to prevent weight loss, improve appetite, and enhance quality of life in patients with some types of cancer, including gastrointestinal cancer, largely because of its ability to reduce the generation of TNF-, degrade TNF- mRNA, and suppress NF-B pathway activation