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In patients with CKD, the relative abundance of Bacteroides fragilis is significantly reduced, and its abundance is significantly negatively correlated with blood urea nitrogen (BUN) and serum creatinine (SCR), which can serve as important targets for the diagnosis and treatment of RF [117]

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Closed comedones form primarily due to the following factors: Overproduction of sebum (oil) by the skin Accumulation of dead skin cells Hormonal fluctuations, particularly during puberty or menstrual cycles In addition to these primary causes, environmental factors such as pollution and humidity can exacerbate the condition

f ), and % relative survival was normalized to vehicle controls

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