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130 In BMSCs and preosteoblast MC3T3-E1 cells, miR-376b-3p directly targets YAP1 to suppress YAP1 expression, and circ_0024097 serves as a ceRNA to rescue YAP1 by absorbing miR-376b-3p, leading to activation of the Wnt/-catenin signalling pathway and cell differentiation, which attenuates osteoporosis

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Although recent advances in understanding MSCs biology are valuable, a shift in research focus toward longitudinal studies integrating genetic, environmental, and lifestyle factors is essential

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