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473 Clinical studies have also identified loss-of-function mutations in GATOR1 components, especially DEPDC5 and NPRL3, in FCD type IIa

The above results indicated that the T-BPH rat model was successfully established, and the prostate of T-BPH rats showed accelerated proliferation activity, decreased apoptosis, shortened G0/G1 phase and down-regulated GPX3 expression, all of which could be reversed by TRO treatment

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Liu J, Zhang Z, Yang Y, Di T, Wu Y, Bian T