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This type of study in ALS patients has several limitations, including the short life span of the patients, which does not allow following markers of oxidative damage for a long time (longitudinal study), and the impossibility of evaluating oxidative damage markers in early disease, as the initial stage of the disease progresses in a subclinical manner, sometimes years before diagnosis[6]

Relaxin-2, a peptide hormone, has demonstrated the ability to restore range of motion and eliminate capsular fibrosis in mouse models of shoulder arthrofibrosis, making it perhaps the most specifically relevant peptide for this condition

IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1

Certain foods contain natural bioactive compounds that help regulate fat metabolism, reduce inflammation, and influence angiogenesis

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