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The absence of a determined lethal dose in rodent studies reflects that acute toxicity testing did not reach a fatal threshold at doses tested, not that the compound has been proven safe at all doses or via all routes over extended periods in any species

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This stacking behavior complicates medication reconciliation and increases uncertainty surrounding glycemic stability, fluid shifts, and inflammatory response

EDS can impact multiple systems at once, which is why symptoms can seem unrelated

Unlike many therapeutic peptides, DSIP does not have a single well-characterized receptor