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This study showed that, in glutamine-deprived microenvironments, TAMs began producing interleukin-23 (IL-23) via HIF1 activation

Engineered liposomes targeting hepatic stellate cells overcome pathological barriers and reverse liver fibrosis

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Thus, multiple mechanisms for triggering ferroptosis are possible

By sequestering free iron, FTMT may limit the iron-driven production of reactive hydroxyl radicals via the Fenton reaction 35