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Marty V, El Hachmane M, Amedee T: Dual modulation of synaptic transmission in the nucleus tractus solitarius by prostaglandin E2 synthesized downstream of IL-1beta

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112 Overactivity of the HPA axis may be caused by damaged astrocytes and aberrant GR function

Thus, the clinical benefits for the risk of heart failure and kidney outcomes, except albuminuria, are likely to be a strength of SGLT2is, whereas those for the risk of stroke are a strength of GLP-1RAs (Graphical Abstract)

This includes signals associated with elimination, hunger, thirst, and emotions