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For example, excessive melanin levels can lead to hyperpigmentation dark patches that may appear on different areas of the body, including the face

2013;8:e57998

Piersma et al., 2015

These mutations exacerbate ROS accumulation, leading to oxidative damage within the mitochondrial matrix, which further impairs antioxidant enzymes and diminishes the activity of key protective proteins such as SOD2 (Wang et al., 2018

This study demonstrates the feasibility of inducing subtle BBB disruption non-invasively using low-pulsed electric fields in mice, with the extent of BBB disruption dependent on the applied voltage and number of pulses