glutathione functional groups Glutathione-Mediated Conjugation of Anticancer Drugs

doi: 10.1016/j.molmet.2014.01.005 155 NagarajanSRPaul-HengMKrycerJRFazakerleyDJSharlandAFHoyAJ

References 1 AguileraA.BerdunF.BartoliC.SteelheartC.AlegreM.BayirH.et al (2021)

Together, mimetics that modulate mitochondrial metabolism, including AMPK activators (e.g., AICAR and metformin), AdipoRon, PPAR agonists (e.g., GW501516, GW0742, rosiglitazone, pioglitazone, T3D-959, and bezafibrate), cAMP/CREB activators (e.g., forskolin), and mitochondrial protectants (e.g., MitoQ), support the energy-intensive processes of neuronal repair

Reactions that worsen after 24 hours, persist beyond 96 hours, or produce increasing warmth signal hypersensitivity or infection and require provider evaluation before the next injection

For example, the liver produces cysteine via glutathione catabolism or homocysteine through the transsulfuration pathway, following which it can be recycled through protein degradation (18)