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LA pretreatment (35 mg/kg for 20 days, or 4 g/kg body weight for 30 days) before the occurrence of fatty liver can impede lipid accumulation in the liver both in higher (60% in diet) and in lower (10% in drinking water) fructose intake

The HOMA-IR was calculated using the formula HOMA-IR = fasting glucose (mg/dl) fasting insulin (U/ml)/405

(2015) 2015:CD008655

The exact effects vary based on the drugs involved, the amount consumed, and whether other substances were used at the same time

This is a qualitative, mechanistic distinction between the two intervention categories, and it is why the research literature treats endpoint agonism and upstream secretagogue stimulation as fundamentally different manipulations of the somatotropic axis rather than two routes to the same outcome