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To determine laser-triggered JQ1 release, 250 L of FK@IQ-4T1 was added into a 1.5 mL EP tube and 250 L of PBS buffer solution (pH 7.4) containing 0.5 wt% Tween-20 was added on the top of the hydrogel

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However, current data are insufficient

ICIs work by blocking the interactions between immune checkpoints such as CTL-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), and programmed cell death ligand-1 (PD-L1) and their ligands, which releases the inhibitory brakes of T cells and results in the robust activation of immune responses (Fig