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Morales-Vargas et al

doi: 10.7717/peerj.16684 93 CaiXQYangHLiangBQDengCCXueHYZhangJJet al

NQO1 has been shown to interact with NAD+ and SIRT2 during cell division.[ref] Related article: NAD+, NR, NMN and genetics Link to gut health: Animal studies show that a non-functioning NQO1 gene leads to gut impermeability and inflammation (leaky gut)[ref]

Higher concentrations, particularly 100 mg/kg, orally, for 9 days have been linked to a notable decline in beneficial bacteria such as Lactobacillus in poultry birds, with bacterial richness showing a negative correlation with ZnO NPs concentration indicating that excessive exposure may contribute to gut dysbiosis (Feng et al., 2017)

Targeted MS analysis Prior to analysis, 100 fmol of each double SIL-synthetic peptide for the acquisition target(s) were spiked into each sample before injection