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However, NNMT can methylate NAM, converting it to MNAM

Bone-targeted radionuclide therapy can be achieved using 223 Ra-chloride [32], 89 Sr-chloride, 153 Sm-[ethylenediamine tetramethylene phosphonic acid] and 188 Re-[hydroxyethylene diphosphonate] [33]

However, it has been reported that natural products or supplementation therapies have been gaining exponential growth in their utilization over the last few decades in both developed and developing countries due to availability, accessibility, affordability, natural origin, and lesser side effects

Krishna R, Mayer LD

In addition, mitochondrial ROS act as potent activators of redox-sensitive transcription factors, particularly nuclear factor-B (NF-B) and activator protein-1 (AP-1), which amplify inflammatory signaling within the tendon microenvironment (Mller-Eigner and Wojtovich, 2025)