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Cognitive impairment, defined as an intermediate stage between the normal aging process and the onset of dementia, has a multifaceted etiology but specifically in the setting of metabolic disorders is sustained by a spectrum of factors, prominently featuring IR, lipotoxicity, and vascular-systemic inflammation, which are also shared with MASLD

The function of DNMT2 is poorly understood, but it has the enzymatic ability to methylate DNA (Kaiser et al., 2016) and is also considered an RNA methyltransferase (Goll et al., 2006)

Lingvay et al., 2025) plus the Phase 1b pharmacodynamic data (Enebo et al., 2021)

Head SA, Shi WQ, Yang EJ, Nacev BA, Hong SY, Pasunooti KK, et al

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