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Research suggests that NRF2 may play a role in promoting skin epidermal barrier formation and enhancing the differentiation of keratinocytes [38, 39]

Furthermore, AMPK induces autophagy by directly phosphorylating ULK1, a key regulator of autophagosome initiation, and by suppressing the mechanistic target of rapamycin Complex 1 (mTORC1), a known inhibitor of autophagy