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Glucose metabolism regulates T cell activation, differentiation, and functions

Bile acids act as signaling molecules that regulate glucose and lipid metabolism through activation of nuclear receptors, such as farnesoid X receptor (FXR) and G-proteincoupled bile acid receptor 1 (GPBAR1) also called as Takeda G-proteincoupled receptor 5 (TGR5)

This work began with the construction of a scalable synthesis of bioorthogonal NAM derivatives

Therefore, ferroptosis as a nexus linking oxidative stress and inflammation is inevitable to play important roles in the pathogenesis of CVDs such as atherosclerosis, stoke, IRI, and heart failure