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They have irregular borders that may include notches

Therefore, there are multiple factors to consider when outlining the biggest differences between the two melanocortin agonists: Molecular Structure: While both MT1 and MT2 are synthetic analogs of alpha-MSH, they have only four amino acids in common: the sequence His-D-Phe-Arg-Trp (positions three to six in MT2)

screening for contraindications (skin cancer history, strong family history of melanoma, immunosuppression)

This cyclization is a key structural distinction from the linear MT-1

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