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Functionalized SPIONs were able to cross the tumor BBB and to accumulate in the tumor and demonstrated high magnetic resonance contrast potential, confirming the ability of functionalized SPIONs to act as a diagnostic agent for intracranial glioma

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For example, enhancing neuronal glucose uptake and utilization or modulating specific metabolic pathways could provide protective effects against metabolic stress and neurodegeneration (Riera and Dillin, 2015)